Clopidol is a white to off-white or light tan crystalline powder, odorless. It is practically insoluble in water, acetone, ether, and benzene; very slightly soluble in methanol or ethanol when heated; and soluble in dilute alkali (e.g., NaOH) solutions.
CAS No.: 2971-90-6
Mechanism:
Clopidol is a pyridinol-class coccidiostat that acts primarily during the early first-generation schizogony (sporozoite stage — Day 1 of the Eimeria life cycle). It inhibits mitochondrial electron transport in the parasite, thereby blocking pyrimidine nucleotide biosynthesis and preventing sporozoite development and invasion of intestinal epithelial cells.
Usage:
Clopidol is widely used as a feed-additive anticoccidial agent for:
Poultry (Broilers, Turkeys): Prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, E. mitis, etc.—especially effective against E. tenella.
Rabbits: Prevention of intestinal and hepatic coccidiosis (Eimeria spp.).
Typical inclusion rates in complete feed:
Poultry: 125 mg/kg (0.0125%) to 250 mg/kg (0.025%) feed
Rabbits: 200 mg/kg feed
It must be fed continuously throughout the rearing period for optimal prevention. Intermittent or late dosing reduces efficacy.
