Amoxicillin Trihydrate is a broad-spectrum, semi-synthetic aminopenicillin antibiotic derived from penicillin. It is the trihydrate salt form of amoxicillin, designed to enhance stability and bioavailability.
Key Characteristics
Chemical Class: β-lactam antibiotic (aminopenicillin subclass).
Mechanism of Action: Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death. It is typically bactericidal.
Spectrum of Activity: Active against a wide range of Gram-positive and Gram-negative bacteria, including:
Streptococcus pneumoniae, Streptococcus pyogenes (Group A strep)
Haemophilus influenzae, Escherichia coli, Proteus mirabilis
Helicobacter pylori (in combination therapy)
Listeria monocytogenes
Pharmacokinetics
Absorption: Well absorbed orally (~90%), with food having minimal effect on bioavailability.
Distribution: Widely distributed, including into tissues and fluids (e.g., lung, prostate, middle ear effusion). Crosses placenta; low levels in CSF unless meninges are inflamed.
Metabolism/Excretion: Partially metabolized in liver; primarily excreted unchanged in urine via glomerular filtration and tubular secretion. Half-life ~1–1.5 hours (normal renal function).
Presentation: 25 kg/drum
Certificate: GMP, DMF
Shelf life: Min 3 years
